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KMID : 0605620130200030104
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Journal of Korean Society of Biological Psychiatry
2013 Volume.20 No. 3 p.104 ~ p.110
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A Prospective Study on an Association between Apolipoprotein E ε4 and Cognitive Change in Community-Dwelling Elders with Alzheimer’s Disease
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Kang Min-sung
Moon Seok-woo
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Abstract
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Objectives: The aim of this study was to examine the prospective impact of the apolipoprotein E (APOE) ε4 on cognitive performance in the community-dwelling elderly individuals with Alzheimer’s disease (AD).
Methods: The total number of subjects was 30 (12 men and 18 women) who were diagnosed with AD from a Korean project of "Early Detection of Dementia". People aged 65-85 years were included in the analysis. The eight neuropsychological domains from the Korean version of Consortium to Establish a Registry of Alzheimer’s Disease (CERAD-K) were conducted to test subjects. They have been followed at 24-month intervals with the same assessments at each interval. Their cognitive performance at 2 year intervals was compared by the occurrence of the APOE ε4.
Results: The impact of ε4 allele was significant in the Word List Memory Test (WLMT, F = 4.345, df = 1, p = 0.021) and Word List Recall Test (WLRT, F = 5.569, df = 1, p = 0.033).
Conclusions: The APOE ε4 allele was significantly correlated especially with verbal episodic memory domain in community-dwelling elders diagnosed with AD.
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KEYWORD
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Alzheimer’s disease, Apolipoprotein E, CERAD-K, Prospective study
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